NFKB1 and breast cancer: In cancers that are closely associated with inflammation, such as glioblastoma, breast cancer and osteosarcoma, NF-κB activation was also inhibited by ISA, and so were the upstream IκB kinase (IKK) and IκB, and downstream COX2 (Di et al., 2014; Wang et al., 2016; Xing et al., 2019).