in human lung squamous cell carcinoma, which are: (i) early TLS (CD21- CD23-); (ii) primary follicle-like TLS with differentiated FDC (CD21+ CD23-); (iii) and mature secondary follicle-like TLS with a germinal center reaction (CD21+ CD23+) (10). Here, CR2 is linked to squamous cell lung carcinoma.