This research identified specific CpG sites associated with AD-related neuropathological measures (such as Braak stage, Thal phase, and cerebral amyloid angiopathy scores) and AD-related proteins (e.g., Aβ40, Aβ42, tau, and p-tau) and uncovered region-specific CpG associations between TCX and CER. This evidence concerns the gene MAPT and cerebral amyloid angiopathy.