Methylation alterations in genes such as sirtuin1 (SIRT1), Ankyrin 1 (ANK1), Ribosomal protein L13 (RPL13), Rhomboids family member 2 gene (RHBDF2), and Cadherin 23 (CDH23) have also been implicated in AD pathogenesis, influencing Aβ and tau pathways (Table 2). The gene discussed is MAPT; the disease is Alzheimer disease.