Subsequently, we established the best regression model by a stepwise multivariate Cox regression analysis and confirmed three PVT1-MYC duet-related genes significantly contributing to OS in pancreatic cancer patients (Figure 1K) and the risk score of each patient was calculated using the following formula: Risk score = (0.1428227×expression level of COL17A1) + (0.2784075×expression level of GBP4) + (0.4265105×expression level of CDC6). The gene discussed is GBP4; the disease is familial pancreatic carcinoma.