INSR and Insulin resistance: However, a more recent study observed that deleting the insulin receptor in mouse megakaryocytes and platelets did not induce platelet hyperactivity, albeit platelet count and volume were increased, suggesting that the enhanced platelet activity linked to insulin resistance is unlikely due to the compromised insulin receptor signalling but to the modifications in platelet count and volume parameters promoted by megakaryocyte/platelet insulin resistance in obesity and type 2 DM (T2DM).101