159). Its inhibition depletes the dormant cells but leaves the population of proliferating tumour cells intact (Ref. 159). Effect of down expressed aplasia Ras homologue member I (ARHI) tumour suppressor on dormancy and reduced autophagy in ovarian tumours is observed. Further observations on re-expression of ARHI in ARHI-deficient SKOv3 ovarian cancer cells induced autophagy and blocked tumour growth conclude autophagy-dependent enforced expression of ARHI in dormant cells. Autophagy inhibition may cause elimination of DTCs and avert metastasis (Ref. 160). This evidence concerns the gene DIRAS3 and neoplasm.