RGMB and central nervous system cancer: 11). In 2018, Zhang et al. found that the transcription factor E2F1 can promote the transcription of lncRNA RGMb-AS1 by binding to the promoter region of lncRNA RGMb-AS1 in papillary thyroid carcinoma (PTC). The highly expressed lncRNA RGMb-AS1 promotes the proliferation, invasion and migration of PTC (Ref. 12). Furthermore, it was found that the lncRNA RGMb-AS1 was up-regulated in various malignant tumours, such as cervical cancer, gastric cancer, pancreatic cancer, glioma, osteosarcoma and laryngeal squamous cell carcinoma (Refs 99, 100, 101, 102, 103, 104).