11). In 2018, Zhang et al. found that the transcription factor E2F1 can promote the transcription of lncRNA RGMb-AS1 by binding to the promoter region of lncRNA RGMb-AS1 in papillary thyroid carcinoma (PTC). The highly expressed lncRNA RGMb-AS1 promotes the proliferation, invasion and migration of PTC (Ref. 12). Furthermore, it was found that the lncRNA RGMb-AS1 was up-regulated in various malignant tumours, such as cervical cancer, gastric cancer, pancreatic cancer, glioma, osteosarcoma and laryngeal squamous cell carcinoma (Refs 99, 100, 101, 102, 103, 104). The gene discussed is RGMB; the disease is osteosarcoma.