IDH1 and central nervous system cancer: (Fig. 3) The group is further subdivided into various categories, namely diffuse midline glioma with H3 K27 alterations (note that the term “mutant” has been revised to altered), diffuse hemispheric glioma with H3 G34 mutations, diffuse pediatric-type high-grade Glioma with wildtype H3 and IDH status (which encompasses tumors with diverse genotypes), and infant-type hemispheric glioma.