FN1 and central nervous system cancer: The molecular mechanisms underlying glioma recurrence remain unclear.<h4>Methods</h4>Our study utilized single-cell sequencing, spatial transcriptomics, and RNA-seq data to identify a subtype of FN1 + tumor-associated macrophages (FN1 + TAMs) associated with glioma recurrence.<h4>Results</h4>This study revealed an increased abundance of FN1 + TAMs in recurrent gliomas, indicating their potential involvement as a critical factor in glioma recurrence.