PABPN1 and colorectal adenocarcinoma: Despite the concordance across most datasets, colorectal adenocarcinoma stood out as a striking outlier (median pairwise Pearson correlation coefficient of − 0.14), and known regulators of poly(A) site selection such as PABPN1 and CSTF2T showed no correlation with median 3′ UTR length, unlike in all other analyzed datasets (Fig. 1E–F; Additional file 1: Fig. S1A–D).