Colorectal adenocarcinomas are largely driven by mutations in the gene adenomatous polyposis coli (APC) [20], and inherited loss-of-function mutations in APC cause familial adenomatous polyposis, which carries nearly a 100% risk of colorectal adenocarcinoma development at some point in life [21–24]. The gene discussed is APC; the disease is Familial adenomatous polyposis.