ALB and Hypoglycemia: The counter regulation via the HSA axis triggered by hypoglycemia is initiated by the activation of glucose-excited (GE) and glucose-inhibited (GI) neurons (Steinbusch et al, 2015) in the hypothalamus and in the RVLM (Ritter et al, 2011), both of which project to the splanchnic nerve that innervates the chromaffin cells of the adrenal medulla.