Additionally, we evaluated GeneCompass by in silico deleting more transcription factors (TFs) in various cell types of different species, i.e., STAT1 on human PBMC cells, SMARCA4 on human acute myeloid leukemia cells, CBX8 on mouse embryonic stem cells, and MTA2 on mouse colonic epithelium cells. The gene discussed is STAT1; the disease is acute myeloid leukemia.