To test for the role of the RING domain and the RZ finger, we complemented RNF213KO MEFs with the indicated GFP-RNF213 alleles, followed by infection with S. Typhimurium, L. monocytogenes ΔactA or the RH strain of T. gondii (Figs. 4D–F and EV4). The gene discussed is RNF213; the disease is infection.