Given that VDAC1 oligomers are implicated in the release of mtDNA [23] and considering the protective effect of a VDAC1-oligomerization inhibitor VBIT-4 against cell death [16, 18, 20–22] and mtDNA release [23], as well as the cytokine storm induced by SARS-CoV-2 infection [25], we analyzed the presence of mtDNA in the serum of COVID-19 patients and searched for SARS-CoV-2 protein targeting VDAC1. Here, VDAC1 is linked to COVID-19.