GNRH1 and Infertility: The inability of ovariectomized C451A-ERα females to show the characteristic activation of Kp and GnRH neurons by estrogens converges with the observation of reduced numbers of corpus lutea in gonadally intact C451A-ERα females (Adlanmerini et al., 2014) and suggests that this mutation leads to impaired ovulation and infertility.