PCOLCE2 and cancer: Ongoing in vitro studies have also demonstrated increased expression of collagens (COL1A2, COL3A1, COL5A2, COL12A1, COL15A1, and COL6A3) in the theca interna of the bovine ovarian follicle, leading to their consideration as cellular markers of this structure Studies of human gynecological cancers showed PCOLCE2 as a gene in cancer progression (114).