The global ECM proteome, or "matrisome," includes core ECM proteins such as collagens, proteoglycans, and ECM glycoproteins like PCOLCE2. In cancer research, hub genes are differentially expressed genes that connect various cancer types and influence networks of co-expressed genes, which may with time provide a means of predicting outcomes and guiding clinical applications (143). The gene discussed is PCOLCE2; the disease is cancer.