TARDBP and amyotrophic lateral sclerosis: Similarly, nucleic acids, as biomolecular polyanions, significantly influence protein aggregation, as seen in Tau and amyotrophic lateral sclerosis (ALS)-related RNA binding proteins like TAR DNA-binding protein (TDP-43), fused in sarcoma (FUS), heterogeneous ribonucleoprotein1 (hnRNPA1), and others (32, 33, 34, 35).