In addition, studies have suggested that activation of MET receptor can induce the expression of various transcription factors from the ETS family such as ETS1 or the PEA3 group members (ETV1, ETV4, ETV5) through the MAPK signalling pathway [46, 51] and, in hepatocellular carcinoma, a regulation loop between ETV1 and HGF expression through MET pathways [43]. This evidence concerns the gene ETV4 and hepatocellular carcinoma.