MYH14 and cardiomyopathy: For example, cardiomyopathy‐causing mutations in ventricular myosin heavy chain and the small molecule compounds employed to correct the functional defects can modulate the load‐dependent detachment kinetics of single myosin molecules as reported earlier.[15] The site of mutations within a myosin molecule may affect different intermediate states in the cross‐bridge cycle, and thereby load dependent kinetics.