Elevated levels of LPS perpetually activate TLR4 in hepatic macrophages and astrocytes initiating the NF‐κB signaling pathway, fostering cytokine secretion such as IL‐6, and culminating in liver inflammation and oxidative damage.[31] IL‐6, a pivotal cytokine in HCC progression, orchestrates a spectrum of cellular responses in hepatocytes, Kupffer cells, and hepatic stellate cells, promoting the oncogenesis, progression, and metastasis of HCC.[32] As an inflammation‐related cancer, HCC progression is associated with inflammation severity. The gene discussed is TLR4; the disease is inflammation.