ID1 and neoplasm: Of note, the expression of BMP-target genes ID1 to 4 was previously reported to be strongly decreased in pDMG cell lines in which the K27M mutation was removed by CRISPR-Cas9 (Harutyunyan et al., 2019), suggesting that even the maintenance of BMP activation in a pool of tumor cells relies on the specific K27M-mediated epigenetic context.