However, while the pro-tumorigenic activity of BMP signaling is clear in ACVR1 mutant pDMG, recent data have unexpectedly reported that BMP ligands may exert a tumor-suppressive activity in H3.3K27M-ACVR1 wild-type (WT) pDMG cellular models (Sun et al., 2022). Here, ACVR1 is linked to neoplasm.