To clarify this point, we first compared tumor clustering according to their ACVR1 status, based on the transcriptional profiling of 193 BMP pathway target genes as a reliable readout of the pathway activation state, including notably the downstream transducers ID1, ID2, RUNX2, and GATA3 (see list in Supplementary file 1a). This evidence concerns the gene ACVR1 and neoplasm.