Integration of all these data unveiled that the BMP-responsive (i.e. High PROGENy TGF-β/BMP score) pool of tumor cells correlates significantly with BMP receptors expression, in particular to BMPR2, BMPR1B, BMPR1A, and ACVR1 levels, respectively in 8, 5, 5, and 4 out of 10 samples (Figure 3E–F and Figure 3—figure supplement 1F). The gene discussed is ACVR1; the disease is neoplasm.