Keeping in mind that BMP2 appears to be dynamically regulated by tumor cells upon stress, these data suggest that activation of the BMP pathway may be finely regulated in pDMG to be maintained at optimal pro-oncogenic levels, without triggering the tumor-suppressive effects (Sun et al., 2022) or negative regulatory loops associated with its over-activation (Christiaen et al., 2010; Afrakhte et al., 1998; Akizu et al., 2010; Bénazet et al., 2009). Here, BMP2 is linked to neoplasm.