Dysregulation of mTORC1 signaling is associated with human neurological disorders, including mood disorders, mental retardation syndromes, autism spectrum disorders, and memory impairment.[7, 8, 17] Hippocampal volume was significantly reduced in the patients with major depressive disorder compared with people without depression.[18] In this study, we found that brain‐specific RagA overexpression caused depressive‐like behaviors and memory deficit (Figure 2A–K). The gene discussed is RRAGA; the disease is depressive disorder.