Of thirteen depression‐associated DRPs, seven proteins including DDC, FGFR2, KIBRA, MED22, OLIG1, RAI1, SLIT2 were upregulated, whereas six proteins including COX3, CRHBP, CSMD1, FSTL1, GRIK4, and LMTK3 were downregulated (Figure 6B). The gene discussed is CRHBP; the disease is depressive disorder.