Of thirteen depression‐associated DRPs, seven proteins including DDC, FGFR2, KIBRA, MED22, OLIG1, RAI1, SLIT2 were upregulated, whereas six proteins including COX3, CRHBP, CSMD1, FSTL1, GRIK4, and LMTK3 were downregulated (Figure 6B). This evidence concerns the gene CRHBP and major depressive disorder.