When comparing quintiles of SHBG using the model adjusted for FRAX- and comorbidity-related predictors (model 3), lower SHBG concentrations were strongly associated with lower risk of any, hip, and forearm fractures (HR Q1 vs Q5, any fracture 0.71, 0.67-0.75, hip fracture 0.55, 0.47-0.65; forearm fracture 0.62, 0.52-0.74, Table 3). The gene discussed is SHBG; the disease is bone fracture.