Of the 3 members without multinodular goiter, 2 (R483H I-6 and III-2; see Fig. 2B) harbored no mutation in KEAP1, and 1 (R483H III-1; see Fig. 2B) had the same mutation as the proband but had no goiter or nodular lesions at age 22 at follow-up. This evidence concerns the gene KEAP1 and goiter.