During an acute infection, activated CD8+ T cells undergo a metabolic shift from OXPHOS to glycolysis.[28] Glycolytic metabolism is essential for CD8+ T cells effector function and cytolytic activity.[21, 29] Increased OXPHOS in Siglec‐G+ T cells may be associated with decreased glycolysis, potentially resulting in dampened T cells effector function. This evidence concerns the gene CD8A and infection.