Consistent with these findings, single‐cell RNA sequencing data of immune cells from early CRC patients revealed that Siglec‐10 was primarily expressed on the exhausted cluster of CD8+ tumor infiltrating lymphocytes (TILs), characterized by inhibitory gene expression (Pdcd1, Havcr2, Tigit, and Lag3) (Figure 2C,D; Figure S3B,C, Supporting Information). This evidence concerns the gene LAG3 and colorectal carcinoma.