Within the present research, PdH served as a hydrogen carrier and self‐catalyst nanozyme, effectively scavenging ROS and exerting anti‐inflammatory effects.[24] During pathological disc degeneration, NP cells established extensive crosstalk with macrophages, which were recognized as the main effectors regulating the inflammatory response in IDD.[46] This study revealed that the PdH‐Apt nanozyme significantly increased the proportions of CD206+/CD86– M2 macrophages. The gene discussed is MRC1; the disease is intervertebral disk degenerative disorder.