Studies have shown that elevated DNMT1/3a or DNMT3b levels in patients with idiopathic pulmonary fibrosis and obesity can cause DNA methylation of the PPARγ promoter, thus suppressing PPARγ expression.[33] Our findings revealed increased DNMT3b and decreased PPARγ after LPS stimulation. Here, DNMT3B is linked to obesity due to melanocortin 4 receptor deficiency.