CRH and major depressive disorder: The presence of depression-related polymorphisms in the BDNF and CRH genes and the elevated expression of inflammatory factors in the blood of individuals with depression provide evidence that anxiety—depression could not only result from the disfiguring appearance of vitiligo but could also play a significant role in the induction or exacerbation of the condition, thus affecting treatment outcomes (Kussainova et al., 2022; Patel et al., 2017).