Virotherapy treatment with either OV-Fc or OV-CXCR4-A reduced the MVD by approximately twofold compared to the untreated tumor along with increased luminal diameters (Fig. 1f and g), supporting the previously reported pruning ability of OVs by infecting proliferating tumor vascular ECs24, 27. The gene discussed is CXCR4; the disease is neoplasm.