In our study, we provide conclusive evidence that the LRRK2 p.L1795F variant is pathogenic by leveraging genome-wide genotyping and whole-genome sequencing data from the Global Parkinson’s Genetics Program (GP2, http://gp2.org/), along with additional data from the Accelerating Medicines Partnership in Parkinson’s Disease (AMP-PD), PDGENEration (PDGENE) and the CENTOGENE database. Here, LRRK2 is linked to Parkinson disease.