In a study for the treatment of paclitaxel-resistant breast cancer, it was observed that LINC00115 was strongly upregulated in paclitaxel-resistant BCSC, and that LINC00115 acted as an RNA linker recruiting the SETDB1/PLK3 complex to activate the HIF1α signaling pathway (34). The gene discussed is HIF1A; the disease is breast carcinoma.