(15) reported that morning fatigue was associated with variations in TNF-α rs1800629 (95% CI: 0.252–0.910, p = 0.025) and rs3093662 (95% CI: 1.796–24.171, p = 0.004), whereas evening fatigue correlated with TNF-α rs2229094 variation (95% CI: 1.389–10.110, p = 0.009), with the C allele of TNF-α rs2229094 associated with increased risks of coronary artery disease and type 2 diabetes. This evidence concerns the gene TNF and type 2 diabetes mellitus.