We studied tumor-reactive CD8+ T cells using a high-dimensional, integrated approach utilizing three human scRNA-seq data sets (including appropriate per-patient analysis), human CODEX imaging, murine models, in vitro assays, and ex vivo systems in livers and primary tumors.55 Both in mice and patients, we found an unexpectedly high frequency of tumor-reactive CD8+ T cells in liver metastasis. This evidence concerns the gene CD8A and neoplasm.