HSPA1A and neoplasm: Additionally, TRM T cells have been correlated to improved response to immunotherapy as these cells can be locally activated to provide anti-tumor function.33–35 The majority of pTRT cells in the lymph nodes were HSPA1A+ which is enriched in stressed T cells correlating to clinically nonresponsive tumors (Figure 3G).36 The lymph node pTRT cells also highly expressed proliferative marker MKI67 (Figure 3G).