Previous studies have found key chemokines and ligands involved in both metastasis of other cancer types as well as liver fibrosis.58–60 Specifically, TGF-beta and IL-6 are one of the few cytokines overlapping in both fields of study.58–60 TGF- β has previously been found in both prostate cancer and breast cancer to induce distant bone metastasis by establishing driver gene mutations that create a premetastatic niche in distant tissue.58,59 Similarly, IL-6 was identified as a mediator for cross-talk between bone marrow and cancer cells in breast cancer models. This evidence concerns the gene IL6 and cancer.