Finally, many of the transcriptional changes which we observed, pSyn pathology-dependent or not, have been reported in other models of synucleinopathy or in human tissue (e.g., Dnajb6, Hspa4l, Hsph1, Gabarapl1, Map1lc3b, Ctsb, Ctsd, Pink1, among others)5, 73–76, indicating that broader α-synuclein-related cellular dysfunction is reflected in α-syn-tg mice. Here, CTSB is linked to synucleinopathy.