CX3CL1 and breast cancer: Additionally, the well-studied chemokine interaction between ‘CX3CL1’ (C-X3-C chemokine ligand 1) and ‘CX3CR1’ (C-X3-C chemokine receptor 1) [94] is prominent in BrighTNess (Figure 4F; see PPI network in Supplementary Figure 6G) and known to be involved in progression and metastasis across multiple cancers including BC, presenting a promising pan-cancer target [95][96][97][98][99][100].