Racil et al. (2013) concluded that improvements in body composition and lipid profiles were associated with cardiovascular adaptations, reducing HOMA-IR in young obese women. On the other hand, studies still present conflicting data regarding the association of PTX3 with adiposity and insulin resistance in various diseases (Hollan et al., 2010; Chu et al., 2012). The reason for this may be related to the number of subjects and the type of exercise applied. However, the current study found a weak negative association of PTX3 with insulin and HOMA-IR (Table 6). Here, PTX3 is linked to Insulin resistance.