XDH and hyperuricemia: Gout and hyperuricemia are often treated with urate-lowering therapy (ULT) such as xanthine oxidase inhibitors, uricosuric drugs, uricolytic enzymes, losartan, and sodium-glucose cotransporter-2 inhibitors (Dalbeth, Merriman & Stamp, 2016; FitzGerald et al., 2020; Richette et al., 2017), although the recent guidelines advise against the routine treatment of asymptomatic hyperuricemia in the absence of related symptoms or conditions (FitzGerald et al., 2020).