COL1A1 and osteogenesis imperfecta: Collagen degradation markers sCTx1 and uDPD were increased to a higher degree in OI mice with collagen mutations, with an overall effect size of 1.80 (CI: 0.97, 2.62) for OI mouse models with mutations in Col1a1 and 1.93 (CI: 0.98, 2.88) for OI mice with mutations in Col1a2, compared with OI mice with mutations in other genes 0.90 (CI: 0.28, 1.52) (Figure 5A).