COL1A1 and osteogenesis imperfecta: For animal studies, we identified 11 strains of OI mice (Figure 1D, Table 2), with 6 studies reporting OI mice with Col1a2 mutation (G610C+/−, Oim−/−, Oim+/−), 3 studies in OI mice with Col1a1 mutation (Col1a1Jrt1/+, Brtl−/−), 3 studies in mice with Wnt1 mutation (Wnt1prrx1−/−, Wnt1sw/sw, Wnt1+/G177C, Wnt1G177C/G177C), and 4 studies reporting data for mice with other OI-associated mutations (Crtap−/−, Bril−/−).