For instance, the nasopharyngeal carcinoma cell-derived exosomes RNF126 (43), glioma cell-derived EVs miR-3184-3p (44) and miR-10b-5p (45) altered the tumor immune microenvironment and aggravated tumor progression by up-regulating the expression of M2 polarization-associated factors IL-10, TGF-β, CD163, and Arg-1, as well as down-regulated the expression of M1 polarization-associated factor TNF-α. Here, TGFB1 is linked to central nervous system cancer.