SIRT5 and diabetic kidney disease: In diabetic cardiomyopathy(DCM), SIRT5 suppresses cardiomyocyte pyroptosis via lysine demalonylation of glutathione S-transferase P (GSTP1) in DCM mice (241), while in diabetic kidney disease, SIRT5 may regulate non-mitochondrial ATP production by decreasing malonylation in the kidney cortex of type II diabetic male BKS db/db mice (242).