RELA and rosacea: Aging-conferred Sirt7 depletion induced a rapid increase in the production of TNF-α, IL-6, and IL-1β by TLR2-NF-κB pathway in LL37-induced rosacea-like mice model (150), and Sirt7 knockdown promotes nuclear translocation of NF-κB p-p65 (phosphorylated p65) and subsequently increases downstream inflammatory cytokine secretion, while SIRT7 overexpression has the opposite effect (80, 151).