KLF15 and renal fibrosis: In renal tissue, SIRT7 alleviates renal cell ferroptosis, lipid peroxidation, and partial epithelial-mesenchymal transition under hypertensive conditions by facilitating the Kruppel-like factor 15 (KLF15)/NRF2 signaling, thereby mitigating renal fibrosis, injury, and dysfunction in hypertensive mice (145).