During Th9 cell differentiation, SIRT1 is selectively suppressed by transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1), which negatively regulates mTOR and HIF-1α signaling activity, together with glycolysis metabolism, suppresses CD4+ T cell interleukin 9 (IL-9) production, alleviates allergic airway inflammation, and promotes malignant tumor growth (70). This evidence concerns the gene IL9 and cancer.