MAPK3 and acute respiratory distress syndrome: SIRT6 can activate autophagy and inhibit the ERK1/2 pathway by negatively regulating H3K9Ac levels in the ERK1/2 promoter, thereby attenuating cisplatin-induced kidney injury, in terms of renal dysfunction, inflammation, and apoptosis (128); however, in LPS-induced acute respiratory distress syndrome, SIRT6 expression is significantly down-regulated, thereby activating the ERK1/2 pathway and exacerbating inflammation, apoptosis, and tight junction protein loss (129).