In terms of lipid accumulation, long non-coding RNA maternally expressed gene 3 (LncRNA MEG3) up-regulates Sirt6 by ubiquitinating enhancer of zeste homolog 2 (EZH2), which suppresses lipid accumulation and inflammation in vitro and alleviates nonalcoholic fatty liver disease in vivo (106). This evidence concerns the gene EZH2 and metabolic dysfunction-associated steatotic liver disease.