However, SIRT1 enhances transcription of the gluconeogenic genes, G6pc and Pck1, by deacetylating peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and Forkhead box O1 (FOXO1) in Sv40 hepatocytes and H4IIE rat hepatoma cells (56, 57). This evidence concerns the gene FOXO1 and hepatocellular carcinoma.