MMP9 and Arthritis: For example, SIRT2 suppresses inflammatory responses in collagen-induced arthritis by deacetylating K310 of NF-κB p65, leading to reduced expression of NF-κB-dependent genes, including those encoding IL-1β, IL-6, monocyte chemoattractant protein 1 (MCP-1), matrix metalloproteinase 9 (MMP-9), and MMP-13 (171).