Besides, SIRT6 attenuates LPS-induced inflammation and lung epithelial cell apoptosis in acute lung injury (ALI) by inhibiting angiotensin converting enzyme 2 (ACE2)/STAT3/Pim-1 proto-oncogene, serine/threonine kinase (PIM1) signaling (132). This evidence concerns the gene SIRT6 and acute respiratory distress syndrome.