SIRT2 and fatty liver disease: discovered that SIRT2 deacetylates HNF4α to prevent liver steatosis and lipid metabolic disorders (158); however, SIRT2 deficiency aggravates diet-induced nonalcoholic fatty liver disease by promoting gut microbiota dysbiosis and lipid deposition and changing the normal metabolites in the presence of palmitic acid, cholesterol, and high glucose (159).