discovered that SIRT2 deacetylates HNF4α to prevent liver steatosis and lipid metabolic disorders (158); however, SIRT2 deficiency aggravates diet-induced nonalcoholic fatty liver disease by promoting gut microbiota dysbiosis and lipid deposition and changing the normal metabolites in the presence of palmitic acid, cholesterol, and high glucose (159). The gene discussed is SIRT2; the disease is metabolic dysfunction-associated steatotic liver disease.