Compared with normal renal tissue, the mRNA expression of CXCR3/CXCL9/10/11 in renal cell carcinoma was significantly increased (89), and the upregulation of CXCR3 expression in renal cell carcinoma was related to the hypoxic state in TME (90). This evidence concerns the gene CXCL9 and renal cell carcinoma.