Compared with normal renal tissue, the mRNA expression of CXCR3/CXCL9/10/11 in renal cell carcinoma was significantly increased (89), and the upregulation of CXCR3 expression in renal cell carcinoma was related to the hypoxic state in TME (90). The gene discussed is CXCL9; the disease is hereditary clear cell renal cell carcinoma.