Similarly, in cholangiocarcinoma, METTL14 mediates m6A modification of Siah2 and promotes the degradation of Siah2 upon reading by YTHDF2, inhibiting the ubiquitination of PD-L1 mediated by Siah2, ultimately leading to an increase in PD-L1 expression levels (128). The gene discussed is SIAH2; the disease is cholangiocarcinoma.