Patients with oral squamous cell carcinoma exhibiting a high m6A score are more likely to experience enhanced efficacy from treatments targeting the PD-1 and CTLA-4 pathways (155), lung squamous cell carcinoma (156), soft tissue sarcoma (157), gastric cancer (102), and hepatocellular carcinoma (158), while a low m6A score suggests greater sensitivity to immunotherapy in thyroid cancer (159), NSCLC (160), follicular lymphoma (161), breast cancer (162), and head and neck squamous cell carcinoma (163). This evidence concerns the gene CTLA4 and hepatocellular carcinoma.