In myeloid cells, METTL3 activates the NF-κB pathway and STAT3 signaling, leading to M1 and M2-like polarization of macrophages, and fosters the proliferation and spread of cancer cells, contingent upon the infiltration of M1 and M2 phenotype-like TAMs (63), and maintains YTHDF1-mediated SPRED2. This evidence concerns the gene METTL3 and cancer.