HMOX1 and Sepsis: Specifically, MaR1 upregulated the expression of Nrf2 and heme oxygenase-1 (HO-1) in a dose-dependent manner and inhibited phosphorylation of p38, ERK1/2, NF-κB p65 and IκBα, promoting an anti-inflammatory M2 macrophage phenotype in sepsis-induced acute liver injury mice.