CD1d- and Jα18-deficient mice lacking iNKT cells are highly susceptible to acetaminophen (APAP)-induced liver injury (AILI) (39, 40), a severe consequence of sudden hepatocyte injury, often induced by APAP overdose in developed countries (41), but the critical iNKT cell subset involved and the role of epigenetic modification remain unknown. The gene discussed is CD1D; the disease is injury.