PIM1 and lobular neoplasia: Further in vitro and in vivo studies suggested that PIM1 can regulate the activation of the NLRP3 inflammasome by regulating intracellular Ca2+, while PIM1 inhibition suppresses NFATc1 signaling and NLRP3 inflammasome signaling in mouse and human podocytes, thus improving the clinical symptoms and pathological damage of LN (7).