PIM1 and airway hyperresponsiveness: Moreover, inhibition of PIM1 kinase activity prevents the development of goblet cell metaplasia, eosinophilic airway inflammation, and airway hyperresponsiveness and increases Th2 cytokine concentrations in bronchoalveolar fluid in a dose-dependent manner, revealing the key role of PIM1 in the full development of allergen-induced airway responses.