In addition, lactate-induced lactylation of histone H3 lysine 18 residue (H3K18la) is found to increase the production of inflammatory cytokines such as IL-2, IL-5, IL-6, IL-8, IL-10, IL-17, IFN-α, and arginine (Arg) in patients, thereby accelerating the development of an anti-inflammatory response of macrophages in sepsis (205). This evidence concerns the gene IL10 and Sepsis.