Furthermore, we show that expression of angiotensin type 1 receptor (AT1R) is increased in the peritoneal macrophage of DOCA/salt hypertensive mice, and specific knockout of AT1R in myeloid cells attenuates macrophage recruitment in vascular wall and reduces heart and vascular hypertrophy and fibrosis without significant reduction in blood pressure (133). The gene discussed is AGTR1; the disease is vascular smooth muscle hypertrophy.