For instance, both NEPC and SCLC share common genetic alterations (e.g., TP53/RB1/PTEN loss, MYC amplification), expression of NE master TFs (e.g., ASCL1, NEUROD1, FOXA2, SOX2), epigenetic alterations (e.g., DNMT, EZH2), the surface markers (e.g., DLL3, TROP2, FGFR), secreted protein (UCHL1), and nuclear exporter (XPO1) overexpression. The gene discussed is UCHL1; the disease is small cell lung carcinoma.