EP300 and pancreatic ductal adenocarcinoma: reported that E1A binding protein p300 (P300) and HDAC2 not only regulate histone acetylation, but also exert as the potential writer and eraser of histone lactylation in pancreatic ductal adenocarcinoma cells, respectively, indicating that acetylation and lactylation may competitively bind to the same histone lysine site and this competitive modification can exert complex regulatory effects on gene expression, influencing the process of NEtD.