This activation decreases RNA expression of the ferroptosis suppressors SLC7A11 and FTH and increases expression of the ferroptosis promoter long-chain-fatty-acid-CoA ligase 4 (ACSL4), pointing to the involvement of NF-κB and hence ferroptosis in the pathogenesis of diabetic cardiomyopathy. Here, ACSL4 is linked to diabetic cardiomyopathy.