Furthermore, different Raf isoforms exhibit different propensities for conferring the oncogenic properties of mutant KRAS, with C-Raf essential for the oncogenic signalling associated with KRas G12V mutations in Non-Small Cell Lung Cancer (NSCLC) mouse models, and indeed in KRAS G12S, G12C, and G12V-mutant cell lines (Blasco et al., 2011). Here, RAF1 is linked to non-small cell lung carcinoma.