KRAS and lung cancer: Ral-selective allosteric inhibitors BQU57 and RBC8, which are selective for Ral-GDP, have been shown to prevent downstream signalling, colony formation and xenograft-tumour growth of a human lung cancer cell line H2122, which is KRAS G12C and p53-mutated (Yan et al., 2014; Phelps et al., 1996).