The roles of PI3K isoforms differ between physiological and disease contexts, with the p110α subunit important in conferring the KRAS-G12D oncogenic effects in myeloid leukaemia, yet exhibiting less importance in physiological haematopoiesis, as determined by normal haematopoiesis occurring in p110α depleted mice, and increased survival of KRas G12D myeloid leukaemia mouse models when p110α was depleted (Gritsman et al., 2014). Here, KRAS is linked to myeloid leukemia.